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Tracing cat domestication through population genetics and capturing genotype-by environment interactions in US beef cattle genomic predictions
(University of Missouri--Columbia, 2022)
Cat domestication initiated as a symbiotic relationship between wildcats and the peoples of developing agrarian societies in the Fertile Crescent. To refine the sites of cat domestication, over 1,000 random-bred cats of ...
Involvement of aberrant chromosome architecture and locus-specific vulnerability to DNA methylation epimutations in bovine large offspring syndrome
(University of Missouri--Columbia, 2022)
Large/abnormal offspring syndrome (LOS/AOS) and Beckwith-Wiedemann syndrome (BWS) are similar congenital overgrowth syndromes which occur naturally in ruminants and humans, respectively. The incidence of these syndromes ...
A systems approach to deriving carcass value from Holstein x SimAngus cattle in an accelerated finishing model
(University of Missouri--Columbia, 2023)
[EMBARGOED UNTIL 12/1/2024] Beef x dairy has increased in popularity, altering the U.S fed beef supply. The objective of this dissertation was to evaluate the effect of Holstein x SimAngus (Hol x SimAngus) breeding and ...
Improving the value of pigs with severe combined immunodeficiency through novel transplantation
(University of Missouri--Columbia, 2023)
[EMBARGOED UNTIL 12/1/2024] Continual rapid advances in biomedical research necessitate the efficient development of animal models that translate findings from preclinical studies into the clinics. Traditional animal models ...
An examination of influenza immunity in pigs and their role in assessing antiviral therapies for humans
(University of Missouri--Columbia, 2022)
The lung is dynamic barrier organ with a complex cell population. Pulmonary immune cells must balance an effective and tolerogenic response to keep homeostasis. Due to numerous similarities to the human respiratory system, ...
Discovery and phenotyping of the determinants and receptors of post-fertilization sperm mitophagy
(University of Missouri--Columbia, 2023)
with regard to sperm mitochondrial health is a plant-derived antioxidant known as gallocatechin, identified by collaborative studies involving our laboratory and colleagues at the University of Pretoria, South Africa. Different concentrations of gallocatechin...
Modulation of bovine preimplantation embryonic development and pregnancy by FGF2, LIF, and IGF1
(University of Missouri--Columbia, 2023)
[EMBARGOED UNTIL 12/1/2024] In vitro embryo production enhances genetic selection through capitalizing on superior genetics, improving fertility, and increasing animal efficiency, all of which contribute to sustainable ...